MPI is the preferred first line non-invasive test for patients with known or suspected coronary artery disease (CAD).
Coronary Flow Reserve
* Coronary flow reserve (CFR), is also referred to as the quantification of myocardial blood flow, and is the measurement of coronary blood flow in the presence of increased metabolic demand. The quantification of myocardial blood flow is performed in conjunction with PET MPI (positron emission tomography myocardial perfusion imaging) to detect the presence of myocardial ischemia and microvascular dysfunction with greater accuracy than myocardial perfusion imaging alone.
* CFR signifies a medical advancement in the classification of cardiovascular risk and coronary artery disease (CAD) by providing objective, reproducible data with a wider range of diagnostic and prognostic potential. Studies have shown that relying purely on visual assessment of coronary angiography and fractional flow reserve may not only produce false-negative results, but also fail to identify severe microvascular dysfunction.
* It is now known that as many as half of all patients with stable CAD suffer from microvascular dysfunction, which is a non-obstructive form of CAD that can be accurately detected by measuring CFR and myocardial blood flow. CFR with PET MPI is a noninvasive technique that benefits patients who are diagnosed with or may be at risk of future cardiovascular events.
* This technology may be especially beneficial for female patients, whose vulnerability to higher cardiovascular disease death rates has long eluded the capabilities of traditional coronary angiography
* By seeking to diagnose CFR levels among patients, clinics are better equipped to rule out hidden biological risks of ischemic heart disease and offer a more informed and comprehensive course of treatment.
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Cardiac PET is considered the preferred test for the majority of patients who meet appropriate criteria for a chemical (pharmacological) stress imaging test.