Cardiac PET MPI


MPI is the preferred first line non-invasive test for patients with known or suspected coronary artery disease (CAD).

Cardiac PET MPI

Capabilities of the PET system

▪️ 3D Acquisition with CASCADE Scatter Correction allows for lower Cardiac PET doses of approximately 30 mCI (Rb-82) without sacrificing image quality. Lower dose means less radiation exposure for patient and technologist.

▪️ Cardiac Matching Application: This misalignment application allows to correct registration issues with the transmission and emission studies post acquisition. This is achieved by avoiding false reconstruction and reading due to patient motion, and providing high image quality on a daily base.

▪️ Coronary Flow Reserve (CFR) via List-Mode Acquisition: This state-of-the-art acquisition protocol is only found on newer hybrid units. The SCINTRON brings this technology to the ECAT family of PET scanners by allowing users to create multiple data sets with only one acquisition (e.g. Coronary Flow Reserve).

▪️ Quantification Integration: quantification software (we use Cedars Sinai CSI/QPET™).

How it Works


Rubidium 82

Rubidium 82 is the radiopharmaceutical that will be used during your cardiac PET scan. The tracer is not a dye or contrast.

Rubidium is a radiopharmaceutical that will be used during your scan to assess blood flow to the heart muscle.



Lexiscan replaces the physical act of exercise and elicits the same response from your body that would occur if you were actually exercising. The pictures that are taken before and after the Lexiscan injection are then compared to each other to see if there are any differences. Such differences in the pictures helps your cardiologist determine whether there may be any major blockages in your arteries. They can also see if there is damage to the heart muscle after a heart attack.


Electrodes are small flat sticky ECG patches that will be placed on your chest. The electrodes are attached to an electrocardiogram (ECG) monitor that charts your heart’s electrical activity during the test. Your blood pressure, heart rate, and electrocardiogram will be monitored before, during, and after the test.
Coronary Flow Reserve

Coronary Flow Reserve

* Coronary flow reserve (CFR), is also referred to as the quantification of myocardial blood flow, and is the measurement of coronary blood flow in the presence of increased metabolic demand. The quantification of myocardial blood flow is performed in conjunction with PET MPI (positron emission tomography myocardial perfusion imaging) to detect the presence of myocardial ischemia and microvascular dysfunction with greater accuracy than myocardial perfusion imaging alone.

* CFR signifies a medical advancement in the classification of cardiovascular risk and coronary artery disease (CAD) by providing objective, reproducible data with a wider range of diagnostic and prognostic potential. Studies have shown that relying purely on visual assessment of coronary angiography and fractional flow reserve may not only produce false-negative results, but also fail to identify severe microvascular dysfunction.

* It is now known that as many as half of all patients with stable CAD suffer from microvascular dysfunction, which is a non-obstructive form of CAD that can be accurately detected by measuring CFR and myocardial blood flow. CFR with PET MPI is a noninvasive technique that benefits patients who are diagnosed with or may be at risk of future cardiovascular events.

* This technology may be especially beneficial for female patients, whose vulnerability to higher cardiovascular disease death rates has long eluded the capabilities of traditional coronary angiography

* By seeking to diagnose CFR levels among patients, clinics are better equipped to rule out hidden biological risks of ischemic heart disease and offer a more informed and comprehensive course of treatment.

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Cardiac PET is considered the preferred test for the majority of patients who meet appropriate criteria for a chemical (pharmacological) stress imaging test.
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